- 2011
- - Descendants
  - Outstanding Performance by a Cast in a Motion Picture
  - Screen Actors Guild Awards
- - Descendants
  - Best Performance By an Actor in a Motion Picture - Drama
  - Golden Globe
- - Descendants
  - Leading Actor
  - British Academy of Film & Television Arts
- - Descendants
  - Best Actor
  - Academy Award
- - Descendants
  - Outstanding Performance by a Male Actor in a Leading Role
  - Screen Actors Guild Awards
- 2009
- - Up in the Air
  - Best Performance By an Actor in a Motion Picture - Drama
  - Golden Globe
- - Up in the Air
  - Outstanding Performance by a Male Actor in a Leading Role
  - Screen Actors Guild Awards
- - Up in the Air
  - Leading Actor
  - British Academy of Film & Television Arts
- - Up in the Air
  - Best Actor
  - Academy Award
- 2007
- - Michael Clayton
  - Leading Actor
  - British Academy of Film & Television Arts
- - Michael Clayton
  - Best Actor
  - Academy Award
- - Michael Clayton
  - Best Performance By an Actor in a Motion Picture - Drama
  - Golden Globe
- - Michael Clayton
  - Outstanding Performance by a Male Actor in a Leading Role
  - Screen Actors Guild Awards
- 2005
- - Syriana
  - Best Performance By an Actor in a Supporting Role in a Motion Picture
  - Golden Globe
- - Syriana
  - Best Supporting Actor
  - Academy Award
- - Syriana
  - Outstanding Performance by a Male Actor in a Supporting Role
  - Screen Actors Guild Awards
- - Good Night, and Good Luck.
  - Outstanding Performance by a Cast in a Motion Picture
  - Screen Actors Guild Awards
- - Good Night, and Good Luck.
  - Actor in a Supporting Role
  - British Academy of Film & Television Arts
- - Syriana
  - Actor in a Supporting Role
  - British Academy of Film & Television Arts
- 2000
- - O Brother, Where Art Thou?
  - Best Performance By an Actor in a Motion Picture - Comedy or Musical
  - Golden Globe
- 1999
- - ER
  - Outstanding Performance by an Ensemble in a Drama Series
  - Screen Actors Guild Awards
- 1998
- - ER
  - Outstanding Performance by an Ensemble in a Drama Series
  - Screen Actors Guild Awards
- - ER
  - Best Performance by an Actor in a Television Series - Drama
  - Golden Globe
- 1997
- - ER
  - Best Performance by an Actor in a Television Series - Drama
  - Golden Globe
- - ER
  - Outstanding Performance by a Male Actor in a Drama Series
  - Screen Actors Guild Awards
- - ER
  - Outstanding Performance by an Ensemble in a Drama Series
  - Screen Actors Guild Awards
- 1996
- - ER
  - Best Performance by an Actor in a Television Series - Drama
  - Golden Globe
- - ER
  - Outstanding Performance by a Male Actor in a Drama Series
  - Screen Actors Guild Awards
- - ER
  - Outstanding Lead Actor in a Drama Series
  - Emmy (Primetime)
- - ER
  - Outstanding Performance by an Ensemble in a Drama Series
  - Screen Actors Guild Awards
- 1995
- - ER
  - Outstanding Lead Actor in a Drama Series
  - Emmy (Primetime)