- 2011
- - United States of Tara
  - Best Performance by an Actress in a Television Series - Musical or Comedy
  - Golden Globe
- 2010
- - United States of Tara
  - Outstanding Performance by a Female Actor in a Comedy Series
  - Screen Actors Guild Awards
- - United States of Tara
  - Best Performance by an Actress in a Television Series - Musical or Comedy
  - Golden Globe
- - United States of Tara
  - Outstanding Lead Actress in a Comedy Series
  - Emmy (Primetime)
- 2009
- - United States of Tara
  - Outstanding Supporting Actor in a Comedy Series
  - Emmy (Primetime)
- 2006
- - Little Miss Sunshine
  - Best Performance By an Actress in a Motion Picture - Comedy or Musical
  - Golden Globe
- - Little Miss Sunshine
  - Outstanding Performance by a Cast in a Motion Picture
  - Screen Actors Guild Awards
- - Little Miss Sunshine
  - Actress in a Supporting Role
  - British Academy of Film & Television Arts
- 2002
- - The Hours
  - Outstanding Performance by a Cast in a Motion Picture
  - Screen Actors Guild Awards
- - About a Boy
  - Actress in a Supporting Role
  - British Academy of Film & Television Arts
- 1999
- - The Sixth Sense
  - Best Supporting Actress
  - Academy Award
- 1994
- - Muriel's Wedding
  - Best Performance By an Actress in a Motion Picture - Comedy or Musical
  - Golden Globe